Circular RNAs (circRNAs) are novel endogenous non-coding RNAs characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. In this review, we summarize a number of the latest theories regarding the biogenesis, properties and functions of circRNAs. Specifically, we focus on the advancing characteristics and functions of circRNAs in the brain and neurological diseases. CircRNAs exhibit the characteristics of species conservation, abundance and tissue/developmental-stage-specific expression in the brain. We also describe the relationship between circRNAs and several neurological diseases and highlight their functions in neurological diseases.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81301119]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2013BAI09B03]; Beijing Municipal Administration of Hospitals' Youth Programme [QML20160504]
第一作者机构：[1]Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[3]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
通讯作者：
通讯机构：[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[3]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Li Tao-Ran,Jia Yan-Jie,Wang Qun,et al.Circular RNA: a new star in neurological diseases[J].INTERNATIONAL JOURNAL OF NEUROSCIENCE.2017,127(8):726-734.doi:10.1080/00207454.2016.1236382.
APA：
Li, Tao-Ran,Jia, Yan-Jie,Wang, Qun,Shao, Xiao-Qiu&Lv, Rui-Juan.(2017).Circular RNA: a new star in neurological diseases.INTERNATIONAL JOURNAL OF NEUROSCIENCE,127,(8)
MLA：
Li, Tao-Ran,et al."Circular RNA: a new star in neurological diseases".INTERNATIONAL JOURNAL OF NEUROSCIENCE 127..8(2017):726-734
