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Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China

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收录情况： ◇ SCIE ◇ CSCD-C

作者：

机构： [a]Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment (CFSA), Beijing, 100021, China [b]School of Public Health, Physiotherapy & Sports Science, University College Dublin, Dublin, D04 N2E5, Ireland [c]Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing, 100020, China [d]Beijing Centers for Disease Control and Prevention, Beijing, 100013, China

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关键词： China Clostridium botulinum Infant botulism Powdered infant formula

摘要：

Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula (PIF) presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins (BoNTs) and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis (PFGE) revealed that the two strains of C. botulinum isolated from the two samples produced indistinguishable pulsotypes. These findings confirmed this case of type B infant botulism associated with the ingestion of PIF contaminated by type B C. botulinum spores. © 2017 The Editorial Board of Biomedical and Environmental Sciences

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出版当年[2016]版：

大类 | 4 区环境科学与生态学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

最新[2023]版：

大类 | 3 区医学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

JCR分区：

出版当年[2015]版：

Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q2 ENVIRONMENTAL SCIENCES

最新[2023]版：

Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q2 ENVIRONMENTAL SCIENCES

影响因子： 3 最新[2023版] 3.1 最新五年平均 1.906 出版当年[2015版] 1.751 出版当年五年平均 1.653 出版前一年[2014版] 2.204 出版后一年[2016版]

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