机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Neurosurg, Beijing 100038, Peoples R China;[2]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Epigenetic alterations such as aberrant expression of histone-modifying enzymes have been implicated in tumorigenesis. Upregulation of lysine (K)-specific demethylase 5B (KDM5B) has been reported in a variety of malignant tumors. However, the impact of KDM5B in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of KDM5B in glioma. In clinical glioma samples, we found that KDM5B expression was significantly upregulated in cancer lesions compared with normal brain tissues. Kaplan-Meier analysis showed that patients with glioma and higher KDM5B expression tend to have shorter overall survival time. By silencing or overexpressing KDM5B in glioma cells, we found that KDM5B could promote cell growth both in vitro and in vivo. Moreover, we demonstrated that KDM5B promoted glioma proliferation partly via regulation of the expression of p21. Our study provided evidence that KDM5B functions as a novel tumor oncogene in glioma and may be a potential therapeutic target for glioma management. (C) 2014 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81360367, 81160066, 30870719]
第一作者机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Neurosurg, Beijing 100038, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Neurosurg, Beijing 100038, Peoples R China;
推荐引用方式(GB/T 7714)：
Dai Bin,Hu Zhiqiang,Huang Hui,et al.Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2014,454(1):221-227.doi:10.1016/j.bbrc.2014.10.078.
APA：
Dai, Bin,Hu, Zhiqiang,Huang, Hui,Zhu, Guangtong,Xiao, Zhiyong...&Zhang, Liwei.(2014).Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,454,(1)
MLA：
Dai, Bin,et al."Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 454..1(2014):221-227
