Objective: To study the treatment effect and safety of diazoxide on patients with congenital hyperinsulinism (CHI). Research design and methods: A total of 44 patients who have been hospitalized to our hospital and used diazoxide as a trial after diagnosis of CHI were chosen as research subjects. The clinical data of the patients were analyzed, and the treatment effects and safety of diazoxide on CHI were evaluated. Results: In the 44 patients studied, the blood glucoses of 36 cases recovered to normal level after using diazoxide, indicating that the 36 patients respond to the treatment of diazoxide. Eight cases still showed severe hypoglycemia after using diazoxide for 10 days, which indicated that the eight patients were unresponsive to diazoxide treatment. Eighteen patients suffered the side effect of fluid retention, and 12 patients suffered transient gastrointestinal reactions. Conclusion: Diazoxide is a first-line treatment of CHI with high safety. Most of the patients with CHI were responsive to diazoxide treatment. Diazoxide should be used as a trial immediately after CHI diagnosis was made.
基金：
Program for Beijing Municipal Health Bureau Higher Excellent Talents, China [2011-3-051]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Endocrine & Genet Metab Ctr,Minist Educ, Natl Key Discipline Pediat,Dept Endocrinol, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Endocrine & Genet Metab Ctr,Minist Educ, Natl Key Discipline Pediat,Dept Endocrinol, Fuxingmenwai Nanlishi Rd 56, Beijing 100045, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Endocrine & Genet Metab Ctr,Minist Educ, Natl Key Discipline Pediat,Dept Endocrinol, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Endocrine & Genet Metab Ctr,Minist Educ, Natl Key Discipline Pediat,Dept Endocrinol, Fuxingmenwai Nanlishi Rd 56, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Hu Shuwen,Xu Zidi,Yan Jie,et al.The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism[J].JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM.2012,25(11-12):1119-1122.doi:10.1515/jpem-2012-0224.
APA：
Hu, Shuwen,Xu, Zidi,Yan, Jie,Liu, Min,Sun, Bing...&Sang, Yanmei.(2012).The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism.JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM,25,(11-12)
MLA：
Hu, Shuwen,et al."The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism".JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 25..11-12(2012):1119-1122
