Background: Renal function is usually evaluated by detecting the serum creatinine level. Serum creatinine level is a significant prognostic factor in patients with coronary heart disease, however, a normal range of serum creatinine can mask the established renal insufficiency. Therefore, patients with normal serum creatinine level and reduced estimated glomerular filtration rate (eGFR) are more likely to be ignored before coronary revascularization, similarly, the prognosis of these groups is easily neglected and still indeterminate. Methods: In this study, a total number of 5173 consecutive patients with normal serum creatinine were selected and grouped by eGFR to follow-up and analyze prognosis after coronary revascularization. The serum creatinine ≤1.2 mg/dl was defined normal. eGFR (ml/min/1.73m2) is divided into 3 stages (≥90, 60-89, <60). We compared the groups in respect of the primary outcome of all-cause death, and the secondary outcome of main adverse cardiac and cerebral vascular events (MACCE) - cardiac death, non-cardiac death, nonfatal myocardial infarction (MI), nonfatal stroke and repeat revascularization, at a median follow-up of 549 days. Results: The mean serum creatinine was 0.97±0.32 [0.2, 6.5] mg/dl, with 5256 (87.5%) patients were within the normal limits. Among them, 5173 patients were suitable for our study; 2265(43.8%) patients' eGFR were ≥90 ml/min/1.73m 2 , with the remaining 2713(52.4%) being 60-89 ml/min/1.73m2, 195(3.8%) was 30-59 ml/min/1.73m2, and none (0%) was <30 ml/min/1.73m 2 . During hospitalization, there were statistical significant differences in in-hospital all-cause mortality (p=0.006) and no differences in MACCE (p=0.320) among different groups distinguished by eGFR. During follow-up, there were still statistical significant differences in follow-up all-cause mortality (p=0.002) and no differences in MACCE (p=0.240). In Cox regression analysis, the independent risk factors of all-cause death after coronary revascularization were identified, they were age, body mass index (BMI), left ventricular ejection fraction (LVEF), history of diabetes mellitus, indication for revascularization, number of diseased cononary artery and failed revascularization; While, only LVEF, number of diseased cononary artery and failed revascularization for MACCE. Conclusions: Normal serum creatinine and reduced eGFR are common among patients who have received coronary revascularization; patients with normal serum creatinine and mild or moderate renal insufficiency are more likely to associated with adverse clinical outcomes. In each group, gender and mode of revascularization may also lead to significant differences in prognosis. Therefore, it is important to estimate eGFR of patients even if their serum creatinine is within normal limits.