机构：[1]Department of Endocrine and Genetics and Metabolism, Beijing Children’sHospital, Capital Medical University, National Centre for Children’s Health, No.56 Nanlishi Road, Xicheng District, Beijing 100045, China首都医科大学附属北京儿童医院[2]Department ofEndocrinology, Fuzhou Children’s Hospital of Fujian Medical UniversityTeaching Hospital, No.145, 817 Middle Road, Gulou District, Fuzhou, Fuzhou350005, Fujian Province, China[3]Department of Pediatric, The secondAffiliated Hospital of Guangxi Medical University, No.166, Daxuedong Road,Nanning, Guangxi, Nanning 530007, Guangxi, China[4]Department ofPediatric, Tianjin Medical University General Hospital, No.154, Anshan Road,Heping District, Tianjin 300052, Tianjin, China[5]Depatment of Endocrinology,Children’s Hospital of Soochow University, No.92, Zhongnan Street,Gongyeyuan District, Suzhou, Suzhou 215025, Jiangsu, China[6]Department ofEndocrinology, Children’s Hospital of Jiangxi Province, No.122, YangmingRoad, Donghu District, Nanchang, Jiangxi, Nanchang 330006, Jiangxi, China[7]Department of Pediatric, Peking University Third Hospital, No.49,Huayuanbei Road, Haidian District, Beijing, Beijing 100191, Beijing, China[8]Center for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children’s Hospital, Capital Medical University, National Centre for Children’sHealth, No.56, Nanlishi Raod, Xicheng District, Beijing, Beijing 100045, Beijing,China职能科室临床流行病与循证医学中心首都医科大学附属北京儿童医院
BACKGROUND: To evaluate the efficacy of GH in improving FAH in ISS children in a multicenter study. METHODS: A real-world observation was carried out. Children with ISS in seven hospitals in China were enrolled. The height gains standard deviation score and the height gain over the target height were evaluated. RESULTS: There were 344 ISS patients (217 boys and 127 girls). The baseline average age of boys and girls was 12.7 and 11.7 years, with bone age of 11.7 and 10.1 years, respectively. The baseline height SDS of boys and girls was - 3.07 and - 2.74, and the FAH SDS was - 1.91 and - 1.38, respectively. Compared with the baseline height SDS, the FAH SDS was significantly increased in both boys and girls (both P = 0.0000). The FAH SDS was the highest (gain by 1.54 SD) in the ≥2y treatment course group. Two hundred eighteen patients (218/344, 63.4%) had a FAH SDS > - 2 SD. Among these patients, girls in the 1-2y treatment course group and ≥ 2y group had a FAH SDS higher than TH SDS. Even in the control group, a spontaneous catch-up growth of 1.16 SD was observed. A multivariate linear regression model was used to analyze the results, with FAH SDS as the dependent variable. It was found that the treatment course and baseline height SDS in the boys' model were statistically significant (P < 0.05), whereas the baseline height SDS and baseline bone age significantly affected the girls' FAH SDS (P < 0.05). CONCLUSIONS: Both girls and boys of ISS improved FAH by GH therapy even if treatments begin over 10 years old and majority of them reached TH. Some peri-puberty ISS will have a spontaneous height gain. We recommend the course of GH treatment more than 2 years for girls, and longer courses for boys.
第一作者机构：[1]Department of Endocrine and Genetics and Metabolism, Beijing Children’sHospital, Capital Medical University, National Centre for Children’s Health, No.56 Nanlishi Road, Xicheng District, Beijing 100045, China
通讯作者：
通讯机构：[1]Department of Endocrine and Genetics and Metabolism, Beijing Children’sHospital, Capital Medical University, National Centre for Children’s Health, No.56 Nanlishi Road, Xicheng District, Beijing 100045, China
推荐引用方式(GB/T 7714)：
Di Wu,Rui-min Chen,Shao-ke Chen,et al.Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty[J].BMC pediatrics.2020,20(1):138.doi:10.1186/s12887-020-02034-8.
APA：
Di Wu,Rui-min Chen,Shao-ke Chen,Ge-li Liu,Lin-qi Chen...&Chun-xiu Gong.(2020).Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty.BMC pediatrics,20,(1)
MLA：
Di Wu,et al."Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty".BMC pediatrics 20..1(2020):138
