机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院[2]Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81571600, 81322018, 81273287]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wan Dongshan,Jiang Wei,Hao Junwei.Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response[J].FRONTIERS IN IMMUNOLOGY.2020,11:doi:10.3389/fimmu.2020.00615.
APA：
Wan, Dongshan,Jiang, Wei&Hao, Junwei.(2020).Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response.FRONTIERS IN IMMUNOLOGY,11,
MLA：
Wan, Dongshan,et al."Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response".FRONTIERS IN IMMUNOLOGY 11.(2020)
