机构：[1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing 100050, China首都医科大学附属天坛医院[2]Department of Neurosurgery, Changhai Hospital, Naval Medical University, 168 Changhai Rd, Shanghai 200433, China[3]Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院神经外科神经科系统[4]Zhengzhou University People’s Hospital, Zhengzhou, China[5]Shanghai Donglei Brain Hospital, Shanghai, China[6]Peking University International Hospital, Beijing, China[7]FirstAffiliated Hospital of Zhengzhou University, Zhengzhou, China[8]First Affiliated Hospital of Xinjiang Medical University, Uruqi, China[9]Qilu Hospital of Shandong University, Jinan, China[10]Nanfang Hospital, Southern Medical University, Guangzhou, China[11]First Affiliated Hospital of Nanchang University, Nanchang, China[12]Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China[13]Second Affiliated Hospital of Nanchang University, Nanchang, China[14]FirstAffiliated Hospital ofHarbinMedical University,Harbin, China
During intracranial aneurysm embolization with the Pipeline embolization device (PED), ischemic and hemorrhagic complications have been observed in cases among Western populations. The postmarket multicenter registry study on the embolization of intracranial aneurysms with the PED in China, i.e., the PLUS study, was performed to assess real-world predictors of complications and functional outcomes in patients treated with the PED in a Chinese population. All patients with intracranial aneurysms who underwent embolization using the PED between November 2014 and October 2019 across 14 centers in China were included. The study endpoints included preoperative and early postoperative (< 30 days) functional outcomes (modified Rankin scale [mRS] scores) and complications related to PED treatment at early postoperative and follow-up time points (3-36 months). Multivariate analysis was performed to identify risk factors for complications. A total of 1171 consecutive patients (mean age, 53.9 +/- 11.4; female, 69.6% [813/1171]) with 1322 aneurysms were included in the study. Hypertension, basilar artery aneurysms, and successful deployment after adjustment or unsuccessful device deployment were found to be independent predictors of ischemic stroke, while the use of the Flex PED and incomplete occlusion immediately after treatment were protective factors. An aneurysm size > 10 mm, distal anterior circulation aneurysms, and adjunctive coiling were found to be independent predictors of delayed aneurysm rupture, distal intraparenchymal hemorrhage, and neurological compression symptoms, respectively. The rate of PED-related complications in the PLUS study was similar to that in Western populations. The PLUS study identified successful deployment after adjustment or unsuccessful device deployment and the degree of immediate postoperative occlusion as novel independent predictors of PED-related ischemic stroke in a Chinese population. Identifier: NCT03831672
基金：
This study was sponsored by the National Key Research and
Development Plan of China (grant number: 2016YFC1300800), the
National Natural Science Foundation of China (grant numbers:
81220108007, 81801156, 81801158, 81471167, and 81671139), the
Special Research Project for Capital Health Development (grant number:
2018-4-1077), and Medtronic, Inc.
第一作者机构：[1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing 100050, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huibin Kang,Yu Zhou,Bin Luo,et al.Pipeline Embolization Device for Intracranial Aneurysms in a Large Chinese Cohort: Complication Risk Factor Analysis[J].NEUROTHERAPEUTICS.2021,18(2):1198-1206.doi:10.1007/s13311-020-00990-8.
APA：
Huibin Kang,Yu Zhou,Bin Luo,Nan Lv,Hongqi Zhang...&Jianmin Liu.(2021).Pipeline Embolization Device for Intracranial Aneurysms in a Large Chinese Cohort: Complication Risk Factor Analysis.NEUROTHERAPEUTICS,18,(2)
MLA：
Huibin Kang,et al."Pipeline Embolization Device for Intracranial Aneurysms in a Large Chinese Cohort: Complication Risk Factor Analysis".NEUROTHERAPEUTICS 18..2(2021):1198-1206
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