机构：[a]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, China[b]Institute of Neuroscience, Soochow University, Suzhou City, China
Epigenetics regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network. Metabolite changes in vivo after stress contribute to histone modification. Histone3-lysine9-beta-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by beta-hydroxybutyrate, may participate in the development of depression. To examine the role of H3k9bhb in depression, experiments were performed on mice and cells. H3k9bhb were reduced in the brain of depressive mice. Exogenous beta-hydroxybutyrate ameliorated depressive behaviors and reversed the reduction of H3K9bhb and BDNF. We showed that H3k9bhb played a role in depression, and firstly linked BHB and BDNF via H3k9bhb. Our findings emphasized the crucial role of metabolic regulation on epigenetics in depression. (C) 2017 Elsevier Inc. All rights reserved.
基金：
The study was supported by the grants from Natural Science
Foundation of China (81601154) and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
第一作者机构：[a]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, China
通讯作者：
通讯机构：[*1]Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou City, China.
推荐引用方式(GB/T 7714)：
Li Chen,Zhigang Miao,Xingshun Xu.beta-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-beta-hydroxybutyrylation[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2017,490(2):117-122.doi:10.1016/j.bbrc.2017.05.184.
APA：
Li Chen,Zhigang Miao&Xingshun Xu.(2017).beta-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-beta-hydroxybutyrylation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,490,(2)
MLA：
Li Chen,et al."beta-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-beta-hydroxybutyrylation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 490..2(2017):117-122
