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Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage

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收录情况： ◇ SCIE

作者：

机构： [1]Vascular Surgery Department of Xuanwu Hospital, Institute of Vascular Surgery, Capital Medical University, Beijing 100053, China, [2]Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA

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关键词： DNA damage Oxidative stress Poly(ADP-ribosyl)ation Poly(ADP-ribose) glycohydrolase Vascular smooth muscle cells

摘要：

Vascular smooth muscle cells (VSMCs) undergo death during atherosclerosis, a widespread cardiovascular disease. Recent studies suggest that oxidative damage occurs in VSMCs and induces atherosclerosis. Here, we analyzed oxidative damage repair in VSMCs and found that VSMCs are hypersensitive to oxidative damage. Further analysis showed that oxidative damage repair in VSMCs is suppressed by a low level of poly (ADP-ribosyl)ation (PARylation), a key post-translational modification in oxidative damage repair. The low level of PARylation is not caused by the lack of PARP-1, the major poly(ADP-ribose) polymerase activated by oxidative damage. Instead, the expression of poly(ADP-ribose) glycohydrolase, PARG, the enzyme hydrolyzing poly(ADP-ribose), is significantly higher in VSMCs than that in the control cells. Using PARG inhibitor to suppress PARG activity facilitates oxidative damage-induced PARylation as well as DNA damage repair. Thus, our study demonstrates a novel molecular mechanism for oxidative damage-induced VSMCs death. This study also identifies the use of PARG inhibitors as a potential treatment for atherosclerosis.

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基金编号： 81470587 CA132755 CA130899 CA187209

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出版当年[2014]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 4 区生化与分子生物学

JCR分区：

出版当年[2013]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 2.9 最新[2023版] 3.9 最新五年平均 1.988 出版当年[2013版] 1.947 出版当年五年平均 1.634 出版前一年[2012版] 2.595 出版后一年[2014版]

第一作者：

第一作者机构： [1]Vascular Surgery Department of Xuanwu Hospital, Institute of Vascular Surgery, Capital Medical University, Beijing 100053, China,

通讯作者：

通讯机构： [1]Vascular Surgery Department of Xuanwu Hospital, Institute of Vascular Surgery, Capital Medical University, Beijing 100053, China, [2]Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA

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