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Altered DNA methylation of the Alu y subfamily in schizophrenia and bipolar disorder

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机构： [1]Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China [2]Center for Reproductive Medicine, The First Affiliated Hospital of University of Science & Technology of China, Hefei, Anhui, China [3]Department of Pediatric Neurology, Affiliated BaYi Children’s Hospital, PLA Army General Hospital, Beijing, China [4]Department of Psychiatry, The Third People’s Hospital of Zhongshan, Zhongshan, Guangdong, China [5]Key Laboratory of Genetics & Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha, China [6]Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong, China [7]Departments of Psychiatry and Behavior Sciences, Cell Biology, and Neurology, Emory University, Atlanta, GA, USA

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关键词： Alu Y families BS-OLE assay DNA methylation psychiatric disorders short terminal repeat retrotransposons

摘要：

Aim: To study DNA methylation patterns of AluY subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). Patients & methods: A bisulfite conversion-specific one-label extension method was employed to detect the AluY subfamily methylation levels of peripheral blood DNA from 92 SCZ patients, 99 BPD patients and 92 controls. Results: Hypermethylation of the AluY A1 and A2 CpG sites in BPD patients and hypomethylation of A3 CpG site in both of BPD and SCZ patients, and opposite age-dependent methylation alterations between SCZ and controls. Conclusion: The differentially altered DNA methylation patterns of the AluY families between BPD and SCZ suggest the role of DNA methylation in the pathogenesis of these major psychiatric disorders. © 2019 Future Medicine Ltd.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区遗传学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区遗传学

第一作者：

第一作者机构： [1]Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China

通讯作者：

通讯机构： [1]Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China

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