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Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children

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资源类型：
作者：
Bin Chen[a,b,c] * ; Jingwen Wang[d] * ; Ying Wang[a,c] * ; Jiaming Zhang[d] ; Changying Zhao[d] ; Nan Shen[a,c] ; Junjie Yang[e] ; Zhongtao Gai[a,c,*1] ; Lei Zhang[a,b,f,*2] ;
机构： [a]Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China [b]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing 100191, China [c]Research Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan 250022, China [d]College of Life Science, Shandong Normal University, Jinan 250014, China [e]College of Life Science, Qilu Normal University, Jinan 250200, China [f]Qingdao Human Microbiome Center, The Affiliated Central Hospital of Qingdao University, Qingdao 266042, China
出处：
DOI： 10.1016/j.intimp.2018.10.017
ISSN：

关键词： Dysbiosis Henoch-Schönlein Purpura Immunoglobulin Oral microbiota

摘要：
Background: The pathogenesis of microbes in allergic diseases has been demonstrated and our previous research indicates that microbiota causing gut disorders in children is associated with Henoch-Schönlein Purpura. However, the role of oral microbiota in Henoch-Schönlein Purpura remains unknown. Method: A total of 164 children were enrolled, of which 98 were patients with HSP and 66 were healthy children. Oral swab samples were collected for DNA extraction and 16S rRNA gene sequencing, then analyzed for oral microbiota composition. Results: Oral microbiota differed between healthy children and those with HSP. Children with HSP exhibited higher oral microbial diversity and richness than the controls. Firmicutes, Proteobacteria, and Bacteroidetes are the dominant phyla in children with HSP. We used linear discriminant analysis (LDA) effect size (LEfSe) algorithm and detected 21 bacterial taxonomic clades showing statistical differences (12 increased and 9 decreased) in children with HSP. The correlation analyses between clinical data and abundance in microbial community indicated that an abundance of Butyrivibrio sp. negatively correlated with the length of hospital stay (LOS). Haemophilus sp. negatively correlated to IgE and IgM but positively correlated to LOS, with decreasing significantly in patients with HSP. Prevotella positively correlated with IgM. Prevotella nanceiensis positively correlated with IgA, and were abundant in children with HSP. Conclusions: These results indicate that children with HSP have significantly different oral microbiota compared to healthy children. Although this study does not imply causality, it is helpful to identify the types and pathways of bacteria that can be used to prevent or treat HSP. © 2018

基金：
We thank all participants in this study, which was supported by the National Natural Science Foundation of China under contract No. 31471202 (Lei Zhang) and No. 81671362 (Zhongtao Gai), the Shandong Provincial Key Research and Development Program under contract No. 2016YYSP009 (Lei Zhang), the Medical and Health Science and Technology Development Projects of Shandong Province No. 2015WSA01023 and 2017WSA01044 (Zhongtao Gai), Weihai Technique Extension Project under contract No. 2016GNS023 (Lei Zhang). Lei Zhang was also supported by the Taishan Scholars Program of Shandong Province (No. tshw20120206 ).
语种：
外文
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
第一作者：
第一作者机构： [a]Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China [b]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing 100191, China [c]Research Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan 250022, China
共同第一作者：
通讯作者：
通讯机构： [a]Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China [b]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing 100191, China [c]Research Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan 250022, China [e]College of Life Science, Qilu Normal University, Jinan 250200, China [f]Qingdao Human Microbiome Center, The Affiliated Central Hospital of Qingdao University, Qingdao 266042, China [*1]Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China. [*2]Qilu Children's Hospital of Shandong University, Jinan 250022, China,Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, China.
推荐引用方式(GB/T 7714)：
Bin Chen,Jingwen Wang,Ying Wang,et al.Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2018,65:doi:10.1016/j.intimp.2018.10.017.
APA：
Bin Chen,Jingwen Wang,Ying Wang,Jiaming Zhang,Changying Zhao...&Lei Zhang.(2018).Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children.INTERNATIONAL IMMUNOPHARMACOLOGY,65,
MLA：
Bin Chen,et al."Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children".INTERNATIONAL IMMUNOPHARMACOLOGY 65.(2018)

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