机构：[1]Department of Surgery, Childrens’ Hospital Affiliated to Soochow University, Soochow University, Suzhou, People’s Republic of China[2]Department of Pediatric, Shanghai Tongren Hospital, Shanghai, People’s Republic of China[3]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, People’s Republic of China
Neuroblastoma (NB) is an embryonic solid tumor derived from precursor cells of the sympathetic nervous system, and accounts for 11% of childhood cancers and around 15% of cancer deaths in children. SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activities. The SUMO proteases (SENP) remove SUMO conjugate from proteins, and their expression is deregulated in diverse cancers. However, nothing is known about the role of SENPs in NBL. In the present study, we found that SENP1 expression was significantly high in metastatic NB tissues compared with primary NB tissues. Overexpression of SENP1 promoted NB cells migration and invasion. Inhibition of SENP1 could significantly suppress NB cell migration and invasion. Moreover, we found that SENP1 could regulate the expression of CDH1, MMP9, and MMP2. In summary, the data presented here indicate a significant role of SENP1 in the regulation of cell migration and invasion in NB and suppress SENP1 expression as promising candidates for novel treatment strategies of NB.
基金：
This work was supported by a Grant from the Natural Science
Foundation of Jiangsu Province of China (BK2011312) and the
Science Foundation of Jiangsu Province Health Department
(Q201304).
第一作者机构：[1]Department of Surgery, Childrens’ Hospital Affiliated to Soochow University, Soochow University, Suzhou, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Surgery, Childrens’ Hospital Affiliated to Soochow University, Soochow University, Suzhou, People’s Republic of China
推荐引用方式(GB/T 7714)：
Yan Xiang-ming,Xu Zhi-qiang,Zhang Ting,et al.SENP1 regulates cell migration and invasion in neuroblastoma[J].BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY.2016,63(3):435-40.doi:10.1002/bab.1375.
APA：
Yan Xiang-ming,Xu Zhi-qiang,Zhang Ting,Wang Jian,Pan Jian...&Zhou Yun.(2016).SENP1 regulates cell migration and invasion in neuroblastoma.BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,63,(3)
MLA：
Yan Xiang-ming,et al."SENP1 regulates cell migration and invasion in neuroblastoma".BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 63..3(2016):435-40
